Transducin

A heterotrimeric GTP-binding protein that mediates the light activation signal from photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual excitation process. Activation of rhodopsin on the outer membrane of rod and cone cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore hyperpolarization of the rod cells.

Also Known As:

Transducin G-Protein (Gt); Transducin, alpha Subunit; Transducin, beta Subunit; Transducin, gamma Subunit; G Protein, Inhibitory Gt; G-Protein Gt, Transducin; Gt G-Protein, Inhibitory; Gt, Transducin G Protein; Inhibitory Gt G-Protein; Transducin G-Protein Gt; alpha Subunit Transducin; alpha Transducin; beta Subunit Transducin; beta Transducin; gamma Subunit Transducin; gamma Transducin; G-Protein, Inhibitory Gt; Gt, Transducin G-Protein; alpha-Transducin; beta-Transducin; gamma-Transducin

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Hydrolases: 2206
    - Acid Anhydride Hydrolases
      - GTP Phosphohydrolases: 2364
        GTP-Binding Proteins: 5712
        Heterotrimeric GTP-Binding Proteins: 269
        Transducin: 189
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Carrier Proteins: 13306
    - GTP-Binding Proteins: 5712
      - Heterotrimeric GTP-Binding Proteins: 269
        Transducin: 189
  - Membrane Proteins: 10262
    - Heterotrimeric GTP-Binding Proteins: 269
      - Transducin: 189
  - Intracellular Signaling Peptides and Proteins: 32
    - GTP-Binding Proteins: 5712
      - Heterotrimeric GTP-Binding Proteins: 269
        Transducin: 189

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Disease

Drug/Important Bio-Agent (IBA)